Curriculum Vitae

• Emaillukaszboryn@gmail.com
• LocationErtingen, Germany
• Work authorizationEU / German resident
• LanguagesEnglish (C2), German (A2)

Experience

1. Senior Research Scientist Boehringer Ingelheim, Computational Innovation, Germany Dec 2023 — Present
   • Built internal python library for single cell QC
   • Established ligand-receptor cell-cell communication best practices (CellChat, NicheNet, LIANA); supported 9 targets via spatial ligand-receptor
   • Developed R and python pipelines with custom AI harnesses to support novel therapeutic concept (NTC) discovery
   • Provided complete benchmarking workflow for bulk RNA-seq deconvolution
2. Senior Bioinformatician Ardigen, Digital CRO, Poland Oct 2020 — Nov 2023
   • Designed macrophage CRISPR screen; hits called via MAGeCK, BAGEL2
   • Set single-cell QC, integration, DGE best practices (scanpy, scVI, DESeq2)
   • Orchestrated and parametrized gene-prioritization workflows using {targets}
   • Mentored the team in single-cell analysis and served as Scrum Master
3. Senior Research Assistant Centre of New Technologies UW, Kobielak Group, Poland Jan 2018 — July 2021
   • Established and maintained bulk RNA-seq and ChIP-seq analysis pipelines
   • PolLASA-certified in GM mouse handling and tissue/cell isolation
   • Optimised ChIP-seq/RNA-seq library prep; Illumina NovaSeq 6000 certified

Education

1. PhD in Molecular Biology The Research Institute of Molecular Pathology 2012 — 2016
2. MSc in Med. Biotechnology University of Łódź 2009 — 2011
3. BSc in Biotechnology University of Łódź 2006 — 2009

Publications

Selected publications.

2018 Nat. Methods

Resolving systematic errors in widely-used enhancer activity assays in human cells enables genome-wide functional enhancer characterization.

Co-first author

• 183citations

• DOI

2023 eLife

Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen specific tumor cell killing by cytotoxic T cells.

Co-author

• 11citations

• DOI

2023 AJRCMB

Transcriptomic and proteomic changes driving pulmonary fibrosis resolution in young and old mice.

Co-author

• 13citations

• DOI